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目的评价哮喘患者不同水平FeNO与炎症表型分布的关系。方法入选南方医院103例支气管哮喘患者,记录一般资料及ACQ7评分。瑞典NIOX MINO系统检测FeNO值,按照ATS 2011年FeNO临床实践指南分组(低水平组FeNO<25μg/L,中水平组25μg/L≤FeNO<50μg/L,高水平组FeNO≥50μg/L),完成肺功能和痰细胞分类检测。炎症表型分为嗜酸性哮喘、中性粒细胞性哮喘、混合粒细胞性哮喘及少粒细胞性哮喘四类。结果不同水平FeNO的哮喘患者人在性别、体重指数、过敏史、ACQ7评分等各组间无显著差异。高水平FeNO组,嗜酸粒细胞哮喘显著多于其他三组(P<0.05),在中低水平组各炎症表型无显著差异(P>0.05)。结论高FeNO水平组哮喘患者嗜酸性炎症高于其他炎症表型,在中低水平FENO组,四种炎症表型分布无显著差异。
Objective To evaluate the relationship between different levels of FeNO and the distribution of inflammatory phenotype in patients with asthma. Methods 103 patients with bronchial asthma from Southern Hospital were enrolled and their general data and ACQ7 scores were recorded. The FeNO value was detected by NIOX MINO system in Sweden according to the ATS 2011 FeNO clinical practice guidelines (FeNO <25μg / L in the low level group, 25μg / L≤FeNO <50μg / L in the middle level group and FeNO≥50μg / L in the high level group) Complete lung function and sputum cell sorting test. Inflammatory phenotype is divided into eosinophilic asthma, neutrophilic asthma, mixed granulocytic asthma and juvenile asthma four categories. Results There were no significant differences in gender, body mass index, history of allergy, ACQ7 scores among all groups with different FeNO levels. High level of FeNO group, eosinophilia group were significantly more than the other three groups (P <0.05), in the low and middle levels of the inflammatory phenotype no significant difference (P> 0.05). Conclusions The eosinophilic inflammation in asthma patients with high FeNO level is higher than that of other inflammatory phenotypes. There is no significant difference in the distribution of the four inflammatory phenotypes in low and medium level FENO patients.