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Curcumin (CUR), a nontoxic polyphenol derived from the rhizome of turmeric (Curcuma longa), has been recognized as a potent anticancer and chemo-preventative agent.However, its clinical application for cancer treatment has been greatly limited due to its poor water-solubility and low bioavailability.In this study, an amphiphilic copolymer based on Pluronic F68 conjugated with CUR (F68-CUR) was designed and synthesized as the carrier to tackle this problem.Highly stable micelles with CUR distributed in the core were formulated via solvent evaporation method, as confirmed by FIRT and NMR.