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  5. Transient augment of IL-1β promotes seizure susceptibility via upregulating CB1 receptor in prolonge

Transient augment of IL-1β promotes seizure susceptibility via upregulating CB1 receptor in prolonge

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：lxhldc
【摘 要】
：
Aim: This study was to investigate the role of IL-1β in the enhanced seizure susceptibility after prolonged febrile seizures (FSs).Methods: Rats or mice pups (P8) were exposed to a hyperthermal chambe
【作 者】
：
Yang-shun TANG Bo FENG Shi-hong ZHANG Zhong CHEN 
【机 构】
：
Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of Chin
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
prolonged febrile seizures epileptogenesis IL-1β CB1R 
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Aim: This study was to investigate the role of IL-1β in the enhanced seizure susceptibility after prolonged febrile seizures (FSs).Methods: Rats or mice pups (P8) were exposed to a hyperthermal chamber (44±2℃) to induce FSs with stereotyped behaviors and epileptic EEG.We injected (icv) IL-1Ra to FSs pups and IL-1β to normal pups or IL-1R1-/-mice.
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