【摘 要】
:
Aim: The translacator protein (18 kDa) (TSPO), previously called peripheral bernzodiazepine receptor, is the key element of the mitochondrial import machinery supplying the substrate cholesterol to th
【机 构】
:
Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China
【出 处】
:
The 12th Meeting of the Asia Pacific Federation of Pharmacol
论文部分内容阅读
Aim: The translacator protein (18 kDa) (TSPO), previously called peripheral bernzodiazepine receptor, is the key element of the mitochondrial import machinery supplying the substrate cholesterol to the first steroidogenic enzyme (P450scc), which transforms cholesterol into pregnenolone, the precursor of all neurosteroids.TSPO have been demonstrated to play an important role in stress-response and stress-related disorders, such as posttraumatic stress disorder (PTSD), anxiety and depression, by means of affecting the production of neurosteroids.
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