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The goal of oncology practice is to use the most effective therapy based on scientific evidence.Currently, the crucial information for the oncologist is pathology diagnosis based on microscopic examination of patients tumor specimen, introduced by Rudolf Virchow in 1845.The understanding that all cancers are associated with genetic changes leads to molecular profiling for every patient based on gene expression studies through the entire neoplastic genome.The approach used by our clinic for individual patients consists of preparation of treatment plans based on individual clinical data, molecular profiling based on tissue and blood specimens, and comparisons to weekly updated database results of clinical trials.