【摘 要】
：
Two G-qudruplex ligands: [Co(H-La)2Cl2](Co1)and [Co(Lb)2][CoCl4]-2H2O(Co2)have been synthesized and characterized.Co1 and Co2 exhibited selective cytotoxici
【机 构】
：
StateKeyLaboratoryCultivationBasefortheChemistryandMolecularEngineeringofMedicinalResources,Schoolof
【出 处】
：
中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
Two G-qudruplex ligands: [Co(H-La)2Cl2](Co1)and [Co(Lb)2][CoCl4]-2H2O(Co2)have been synthesized and characterized.Co1 and Co2 exhibited selective cytotoxicity against T-24,Hep-G2,SK-OV-3,SK-OV-3/DDP,BEL-7402,NCI-H460 and HCT-8 cell lines with IC50 values in the micromolar range(1.0-40.2 μM),but low cytotoxicity toward normal human liver HL-7702 cells.
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