Determination of parabens in pharmaceutical and cosmetic products by capillary electrophoresis

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  Parabens are homologous series of hydroxybenzoic acid, esterified at the C-4 position (including methyl-, ethyl-, propyl-, butyl-, heptyl-and benzyl-paraben).Parabens have been widely used as antimicrobial preservatives in foods.Moreover, parabens are also used in pharmaceutical and cosmetic products because of their broad spectrum of activity.However, it was reported allergic dermatitis of cosmetic products containing parabens.Furthermore, recent studies of the determination of parabens in human breast cancer cells have emphasized the importance of this analysis.Therefore, new simple and precise methods are needed for the determination ofparabens.
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