Investigation on stereoselective metabolism of phencynonate in vitro by the chiral HPLC method

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：dragonunderwater

【摘要】

：

Aim: To investigate the stereoselective metabolism of phencynonate.Methods: Phencynonate enantiomers were isocratically separated and determined by high performance liquid chromatography (HPLC) on a L

【作者】

：

Ying LIU Yu-ying KOU Pin-xiang XU He LIU Ke-liang LIU Ming XUE

【机构】

：

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University,Beijing 100

【出处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

phencynonate chiral drugs drug metabolism cytochrome P450 protein binding Caco-2

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Cannabinoid receptor 2 protects against acute experimental sepsis in mice

Aim: The effects of cannabinoid receptor 2 (CB2R) on the sepsis still remains undefined.Our study is to explore the role and mechanism of CB2R in acute sepsis model of mice.Methods: Survival rate was

会议

cannabinoid receptor 2sepsispro-inflammtory factorproliferationmacrophageT

Structural elucidation of metabolites of lapachol in rats by liquid chromatography-tandem mass spect

Aim: Drug metabolic profile plays an important role in discovering and developing a novel drug from metabolites possessing pharmacological activities.Lapachol is a major active component isolated and

会议

structural elucidationlapacholmetabolitesLC-ESI-MSn

Regulation of CYP3A4/CYP2BG/CYP2C9 transcription through nuclear receptor PXR by helicid and Its met

Aim: To establish and validate an in vitro system to screen drug inducers of CYP3A4,CYP2B6, and CYP2C9 and study hPXR (human pregnane X receptors)-mediated transcriptional regulation of CYP3A4, CYP2B6

会议

helicidhuman pregnane X receptorsCYP3A4CYP2B6CYP2C9

Liquid chromatography-mass spectrometry based metabonomic investigation into the potential biomarker

Aim: To identify and character the biomarkers in mice suffered the repetitive hypoxia.Methods: A metabonomic method utilizing LC-ESI-MSn and multivariate statistical technique has been successfully ap

会议

metabonomicsbiomarkeracute repetitive hypoxiabrainLC-ESI-MS

Assay of plasma protein binding rate of puerarin with microdialysis in vitro tests

Aim: To study the plasma protein binding rate of puerarin.Methods: The microdialysis-HPLC method was applied to determine the plasma protein binding rate of puerarin.Results: The plasma protein bindin

会议

puerarinhigh protein boundingmicrodialysiszero-net fluxHPLC

Contribution of baicalin on the plasma protein binding displacement and CYP3A activity inhibition to

Aim: Baicalin purified from the root of Radix scutellariae has been widely used in clinical practices.This study aimed to evaluate the effect of baicalin on the pharmacokinetics of nifedipine, a CYP3A

会议

baicalinnifedipinepharmacokineticsratsplasma protein binding

Inhibitory effect of baicalin on the plasma protein binding and CYP1A2 activity induce the pharmacok

Aim: To elucidate the effect of baicalin on the pharmacokinetics of theophylline in rats, focusing on plasma protein binding displacement and inhibitory effect on CYP1A2 in vivo and in vitro.Methods:

会议

baicalintheophyllinepharmacokineticsCYP1A2protein binding

Nicotinamide phosphoribosyltransferase Is required for the calorie restriction-induced improvements

Aim: This study was designed to investigate whether nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in the beneficial effects induced by calorie restriction (CR).Methods: FK866,

会议

nicotinamide phosphoribosyltransferaseinsulin sensitivitymetabolismcalorie re

Determination of atomoxetine in human serum by HPLC-UV method using protein precipitation and on-lin

Aim: To develop an HPLC-UV method for the determination of atomoxetine (ATM) in human serum with simple sample preparation and higher automation.Methods: After protein precipitation (PP) of the serum

会议

HPLC-UVhuman serumprotein precipitationon-line solid phase extractionatomoxe

Pharmacokinetic and pharmacodynamic properties of batifiban coadministered with antithrombin agents

Aim: To observe whether antithrombin agents affects the pharmacokinetic and pharmacodynamic properties of batifiban in combination therapy and optimize clinical administration dosage of batifiban.Meth

会议

batifibanglycoprotein Ⅱb-Ⅲa inhibitorsantithrombin agentspharmacokineticspha

Investigation on stereoselective metabolism of phencynonate in vitro by the chiral HPLC method

与本文相关的学术论文