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Aim: The nucleus tractus solitarii (NT5), the principal terminal site of the baroreceptor afferents, contributes to cardiac vagal baroreflex by its connection with the nucleus ambiguus (NA), the origin of the vagus nerve.We investigated the role of vascular endothelial growth factor receptor 2 (VEGFR2), also known as Kdr/Flk-1, in cardiac vagal baroreflex and heart function under resting conditions.