Objectives: Toll/interleukin 1 receptor domain containing protein encoded by E.coli (TcpC) was found to be a virulence factor that promotes bacterial survival and is closely related to the pathogenesi
In early spring 2013,human infections with a novel avian influenza A (H7N9) virus in Eastern China raised concerns of a new influenza pandemic.To address these concerns,the development of a safe and e
Background: Aberrant expression of the RON receptor tyrosine kinase,a member of the MET proto-oncogene family,in breast cancer and non-small cell lung cancer (NSCLC) has therapeutic implication.Here w
目的：乳腺癌是威胁妇女健康的主要恶性肿瘤,内分泌治疗是乳腺癌综合治疗的主要手段之一。他莫昔芬(Tamoxifen,TAM)一直是绝经前妇女乳腺癌辅助内分泌治疗的首选药物,但在其长期治疗过程中可能引起子宫内膜细胞的增殖及肥大,促进子宫内膜不典型增生、息肉甚至浸润性癌的形成,这在一定程度上影响了患者长期受益。但目前对TAM如何导致子宫内膜癌变的具体机制尚未完全阐明,我们将在此探讨p62在其中的可能作用
目的：索拉非尼是目前唯一经临床试验证实对晚期肝癌治疗有效的全身性药物，但其仅2-3个月的生存获益并不令人满意。本研究中，我们探索二甲双胍，目前作为Ⅱ型糖尿病的一线药物，是一种潜在的抗肝细胞肝癌的治疗药物。其与多靶点抑制剂索拉非尼可能发挥协同抑制肝细胞肝癌增殖及促进凋亡的作用。
Purpose: The receptor tyrosine kinase RON is critical in epithelial tumorigenesis and a drug target for cancer therapy.Here,we report the development and therapeutic efficacy of a novel anti-RON antib
Purpose: To determine the relationship of cytokine/chemokine expression with the clinical presentation of hand,foot and mouth disease (HFMD).Methods: This study involved 28 mild HFMD patients,44 sever
Objective: Chitosan is a biodegradable,biocompatible and natural polymer with low immunogenicity that derived from chitin through partial deacetylation.N-(2-hydroxypropyl)-3-trimethylammonium chitosan
Ebolaviruses are highly infectious pathogens that cause lethal Ebola virus disease (EVD) in humans and non-human primates (NHPs).Due to their high pathogenicity and transmissibility,as well as the pot
Objective: It was found that maltose binding protein (MBP) has extensive immunologically regulatory effects,including activation of NK cells,macrophages and Thl cells.In fact,it was also reported that