【摘 要】
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Epstein-Barr virus (EBV) causes human lymphoid malignancies, and the EBV product latent membrane protein 1 (LMP1) has been identified as an oncogene in epit
【机 构】
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CancerResearchInstitute,CentralSouthUniversity,Changsha,Hunan,410078
【出 处】
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第11届海峡两岸细胞生物学学术研讨会
论文部分内容阅读
Epstein-Barr virus (EBV) causes human lymphoid malignancies, and the EBV product latent membrane protein 1 (LMP1) has been identified as an oncogene in epithelial carcinomas such as nasopharyngeal carcinoma (NPC).EBV can epigenetically reprogram lymphocyte specific processes and induce cell immortalization.However, the interplay between LMP 1 and the host cell remains largely unknown.Here,we report that LMP 1 is important to establish Hox gene expression signature in NPC cell lines and tumor biopsies.LMP1 induces stalling of RNA polymerase Ⅱ (Pol Ⅱ) at Hox genes, which is released by irradiation leading to Hox gene reactivation.TET3, but not TET2 or TET1, mediates Hox gene reactivation after irradiation which is accompanied by 5hmC demethylation.Furthermore, we found that HoxC8, one of the genes silenced by LMP1, not only inhibited tumor growth but also up-regulated tricarboxylic acid (TCA) cycle-related genes acting as repressor of the Warburg effect.Accordingly, we propose that viral latency products may repress via stalling key mediators that induce metabolic reprogramming.
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