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  5. Synthesis and In vitro anti-cancer activity of four metal-fluorouracil complexes

Synthesis and In vitro anti-cancer activity of four metal-fluorouracil complexes

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：liuxing_001
【摘 要】
：
Aim: In order to synthesize new efficient and low toxic metal-fluorouracil (5-FU) complexes anticancer drugs.Methods: Copper, iron, zinc salts and fluorouracil were used to synthesize copper, iron and
【作 者】
：
Yi-ping ZHOU Yun ZHOU Ying-jie CHEN Min LUO Zhong-zheng SHI Wer-yuan ZHONG 
【机 构】
：
School of Pharmaceutical Science,Kunming Medical University,Kunming 650500,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
copper iron zinc-fluorouracil complexes synthesis anti-cancer activity 
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Aim: In order to synthesize new efficient and low toxic metal-fluorouracil (5-FU) complexes anticancer drugs.Methods: Copper, iron, zinc salts and fluorouracil were used to synthesize copper, iron and zinc-fluorouracil complexes.Preliminary chemical structures of the 4 complexes were confirmed by elemental analysis and mass spectrometry.Their inhibitory activity on human cancer cells was measured by MTT colorimetric assay.
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