Aspirin enhanced ABT-737-induced apoptosis via regulation of PI3K pathway in human cancer cells

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：skjthit

【摘要】

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【作者】

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Chong ZHANG Jian-ping PAN Hua ZHOU Si-cong WANG Neng-ming LIN Lin-yi FENG Xiao-dan SHUAI Ya-si XU Dan ZHANG Da-yong ZHANG Bao-ming WANG Li-huang ZHANG Jun-bo WANG

【机构】

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School of medicine,Zhejiang university city college,Hangzhou 310015,China

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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aspirin ABT-737 solid tumors apoptosis autophagy

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Aim: Observational studies show that regular use of aspirin after diagnosis was associated with longer survival among patients with mutated-PIK3CA colorectal cancer, but not among patients with PIK3CA wild-type cancer.ABT-737, a potent small-molecule inhibitor of antiapoptotic members of the Bcl-2 family,is a promising therapeutic agent for multiple malignancies.We examined the anti-cancer activity of 2 chemotherapeutic agents (aspirin and ABT-737) in several PIK3CA wild-type cancer cells.

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Aspirin enhanced ABT-737-induced apoptosis via regulation of PI3K pathway in human cancer cells

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