Aim: Chronic glomerulonephritis (CGN) is a clinical syndrome of glomerular disease which is main characterized by haematuria, proteinuria and edema, has become a global pandemic that severly diminishes the quality of life for millions.By now, treatment options and resources remain woefully antiquated main partly owing to maladaptive animal models and drugs.An osmotic pump controlled cationic bovine serum albumin (C-BSA) delivery to produce CGN is a novel model, which avoids the disadvantages of conventional models and provides a new sight to establish CGN model.