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5. TMEM16A contributes to endothelial dysfunction through accelerating Nox2 NADPH oxidase-derived ROS g

TMEM16A contributes to endothelial dysfunction through accelerating Nox2 NADPH oxidase-derived ROS g

来源 :中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 | 被引量 : 0次 | 上传用户：levmg2

【摘 要】

：

OBJECTIVE The Ca2+-activated Cl-channel (CaCC) plays a crucial role in various physiological functions.Recent evidences suggest TMEM16A encodes CaCC in various cells, including endothelial cells.Howev

【作 者】

：

MA Ming-ming GAO Min GUO Kai-min LI Xiang-yu WANG Mi ZENG Xue-lin SUN Lu LYU Xiao-fei DU Yan-hua WANG Guan-lei ZHOU Jia-guo GUAN Yong-yuan 

【机 构】

：

Department of Pharmacology, Cardiac and Cerebra/Vascular Research Center, Zhongshan School of Medici

【出 处】

：

中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛

【发表日期】

：

2016年11期

【关键词】

：

TMEM16A endothelial dysfunction ROS NADPH oxidase Nox2 angiotensin Ⅱ 

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　　OBJECTIVE The Ca2+-activated Cl-channel (CaCC) plays a crucial role in various physiological functions.Recent evidences suggest TMEM16A encodes CaCC in various cells, including endothelial cells.However, the role of TMEM 16A in the vascular endothelial dysfunction in hypertension is unclear.

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