【摘 要】
：
The commercial nerve grafts for repair of middle-or long-segment sciatic nerve defects do not achieve a satisfactory effect in the clinic.Areas of interest currently focus on how to mimic neural regen
【机 构】
：
Orthopedic Institute of the PLA General Hospital, Beijing, China
【出 处】
：
Joint Symposium of 2016 International Neural Regeneration Sy
论文部分内容阅读
The commercial nerve grafts for repair of middle-or long-segment sciatic nerve defects do not achieve a satisfactory effect in the clinic.Areas of interest currently focus on how to mimic neural regeneration niche in the nerve graft using tissue engineering technique and thereby to increase the repairing effects of nerve graft.In the present study,we used a novel tissue-engineered nerve graft,which was made of adipose-derived stem cell (ADSC)-derived extracellular matrix (ECM)-modified and ADSC-compounded chitosan tube,to bridge the defected sciatic nerve and investigated its effects in promoting the recovery of peripheral nerve injury from the perspectives of gait analysis,electrophysiology,histology and target organ evaluation.The tissue-engineered nerve graft increased sciatic function index,compound muscle action potential,diameter of myelinated fibers,thickness of myelin sheath,and cross-sectional area of targeted muscle fibers.The repairing effect of the tissue-engineered nerve graft was superior to that of simple ECM or ADSCs,and it was similar to that of nerve autograft.These results suggest that the novel tissue-engineered nerve graft promoted the recovery of sciatic nerve function and morphology of SD rats,which was close to the effect of nerve autograft.
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