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  5. Preparation of Charge-conversion nanoconjugates based on Poly(β-L-malic acid) for effective and spec

Preparation of Charge-conversion nanoconjugates based on Poly(β-L-malic acid) for effective and spec

来源 :中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：jieminglin
【摘 要】
：
The tumor extracellular environment is more acidic than normal tissues.Therefore,pH-dependent charge conversion systems could be used to realize efficient drug delivery.In this study,a multi-functiona
【作 者】
：
Q.Zhou S.Y.Guo M.F.Cui H.Wu 
【机 构】
：
Department of Pharmaceutical Analysis,School of Pharmacy,Fourth Military Medical University,Xi'an 7
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
【发表日期】
：
2014年6期
【关键词】
：
polymalic acid nanoconjugate pH-sensitive charge-conversion 
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　　The tumor extracellular environment is more acidic than normal tissues.Therefore,pH-dependent charge conversion systems could be used to realize efficient drug delivery.In this study,a multi-functional nanoconjugate based on Poly(β-L-malic acid)(PMLA)was designed for effective and specific drug delivery.Short branched polyethyleneimine(sbPEI)-modified PMLA(PEPM)was synthesized.Fragment HAb18 F(ab)2 and 2,3-Dimethylmaleic anhydride(DMA)conjugated PEPM(HDPEPM)nanoconjugate was constructed.
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