论文部分内容阅读
目的:病理性心肌肥厚和纤维化是心衰发生发展的重要病理基础。可溶性表氧化物水解酶(sEH)是代谢花生四烯酸(AA)CYP450表氧化酶代谢产物EETs的重要水解酶。我们的前期研究表明sEH在血管紧张素II(Ang II)诱导的心肌肥厚过
Objective: Pathological cardiac hypertrophy and fibrosis are important pathological basis for the development of heart failure. Soluble epoxide hydrolase (sEH) is an important hydrolase that metabolizes the metabolites of arachidonic acid (AA) CYP450 epoxide oxidase, EETs. Our previous study showed that sEH had an effect on angiotensin II (Ang II) -induced myocardial hypertrophy