In the first part,I will discuss our progresses on metastasis related studies by useing lectin microarray.Membrane-localized glycans which usually conjugated to proteins and lipids are modifiers of cellular motility processes and thus are of crucial relevance for the onset of cancer metastasis.The aim of this study was to identify altered glycans which take the responsibilities in the metastasis of breast carcinoma cells.To this end,human breast carcinoma cell lines,MDA-MB-231 and its single cell progenies (SCPs) of different metastatic abilities were examined by lectin microarray with 91 lectins.