【摘 要】
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In the central nervous system,excitatory neurotransmitter glutamate is mainly released from neuron and uptaken by astrocyte.In addition to our previous findings that glutamate in astrocyte could be sy
【机 构】
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Neuroscience Research Institute Department of Neu
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
In the central nervous system,excitatory neurotransmitter glutamate is mainly released from neuron and uptaken by astrocyte.In addition to our previous findings that glutamate in astrocyte could be synthesized into glutamine and utilized in TCA cycle for energy metabolism,we observed that glutamate induced progressive nuclear swelling in astrocyte.The rate of nuclear swelling was glutamate concentration dependent.Glutamate-induced nuclear swelling was also observed in isolated astrocytic nucleus,indicating nuclear swelling was a direct effect and independent from cytosolic components.Glutamate-induced nuclear swelling could be modulated by glutamate transporters,but not glutamate receptors.It also required the presence of aquaporin-1,which we identified to be localized on the astrocytic nuclear envelope.Our findings indicated that glutamate in astrocyte could not only affect its metabolism,but also nuclear functions.
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