室温碳氢活化下钯催化四芳基锡参与的Stille偶联反应

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：sfol001

【摘要】

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【作者】

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刘玉霞薛东王超肖建良

【机构】

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陕西师范大学化学化工学院,应用表面与胶体化学教育部重点实验室陕西省西安市长安南路199号中国西安 710062

【出处】

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中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

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2015年7期

【关键词】

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钯碳氢活化氧气吲哚四芳基锡

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　　钯催化的C-H 活化反应是近年来的一个研究热点.吲哚是一类重要的杂环类化合物.长期以来,吲哚类化合物的官能化一直是研究热点,它作为一类重要化合物在药物化学和天然产物合成上具有重要用途1.近几年来,文献中对于吲哚实现直接官能团化已有一些成功的报道2.Stille 偶联反应最早由Eaborn 和Kosugi 小组于1976-1977 年提出3,已经越来越为人们所关注,在医药以及天然产物合成中得到了广泛的应用.但是,有机锡化物和卤代芳烃化合物都有剧毒,且造价高昂,这就使得Stille 偶联反应的应用有了很大的局限性.目前,通过C-H 键活化的Stille 偶联反应的研究是极为少见的.

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室温碳氢活化下钯催化四芳基锡参与的Stille偶联反应

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