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5. Discovery of potent and selective small-molecule inhibitors of TLR9

Discovery of potent and selective small-molecule inhibitors of TLR9

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：Melanzpl1

【摘 要】

：

Dysregulation of Toll-like receptor 9(TLR9) signaling pathway can lead to various immunological diseases,such as systemic lupus erythematosus(SLE) and multiple sclerosis[1-2].Developing a potent and s

【作 者】

：

Yi Yang Juanjuan Du Yin Hang 

【机 构】

：

Center of Basic Molecular Science,Department of Chemistry,Tsinghua University,Beijing 100082,China

【出 处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

TLR9 inhibitor 

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　　Dysregulation of Toll-like receptor 9(TLR9) signaling pathway can lead to various immunological diseases,such as systemic lupus erythematosus(SLE) and multiple sclerosis[1-2].Developing a potent and selective inhibitor with low toxicity is crucial to treat these diseases.

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