【摘 要】
：
The main model for the acute morphine action on the dopamine neurons of the VTA is the disinhibition model.In recent studies show that blocking glutamatergi
【机 构】
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State Key Laboratory of Medical NeurobiologyState Key Laboratory of Medical Neurobiology,Shang hai M
【出 处】
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International Conference for Physiological Sciences 2012(201
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The main model for the acute morphine action on the dopamine neurons of the VTA is the disinhibition model.In recent studies show that blocking glutamatergic signaling in the VTA suppresses the morphine-induced dopamine neuron excitation.However, how acute morphine increases the glutamatergic inputs to the dopamine neurons remains unknown.We explored the mechanism using the whole-cell patch clamp and pharmacological approaches.The results showed that morphine increased the glutamatergic transmission through the disinhibition of GABAB receptor which expressed on the glutamate terminals and tonic inhibited the glutamatergic transmission.Morphine inhibited the glutamatergic transmission through activation of MOR.The combined effect of excitation and inhibition showed enhancement of the glutamatergic transmission.These results show the anatomical organization and functional role of local neuronal circuit for acute morphine action on dopamine neurons.
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