Design and synthesis of 4-hydroxy-N1,N3-diphenyl-1,3-benzenedicarboxamide derivatives as potential a

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：seryhugjkghj

【摘要】

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【作者】

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Dong-En Wu Man-Ning Wang Bai-Wang Sun

【机构】

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College of Chemical Engineering,SouthEast University,Nanjing 211189

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

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2015年3期

【关键词】

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4-hydroxyisophthalic synthesis 4-hydro-N1 N3-diphenyl-1 3-benzenedicarboxamide

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　　In the last few years,a large structural variety of N-aryl-salicylamide derivatives as the potential EGFR PTK inhibitors have been synthesized and studied,which showed efficient antitumor activity1-5.While 4-hydroxyisophthalic acid which is a by-product of the Kolbe-Schmitt reaction have not studied systematically,especially biological activity of its amide derivatives.

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Design and synthesis of 4-hydroxy-N1,N3-diphenyl-1,3-benzenedicarboxamide derivatives as potential a

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