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Accurate localization of the epileptogenic zone(EZ)is essential for the successful surgical treatment of the refractory focal epilepsy.The aim of the present study is to investigate whether a dynamic network connectivity analysis based on stereo-electroencephalography(SEEG)signals is effective in localizing the EZ.SEEG data were recorded from seven patients underwent presurgical evaluation for the treatment of refractory focal epilepsy,and the subsequent resective surgery gave the patients good outcome.