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we described a Rivaroxaban (RIV) nanocrystal for overcoming poor solubility here.The results showed that using dissocubes method with polxamer 188、 Hydroxy Propyl Methyl Cellulose (HPMC) E9 and Sodium Dodecyl Sulfonate (SDS) as stabilizers,mannitol as freeze-drying protective additive,RIV nanocrystal was produced quickly,the average size of nanocrystal was 186.6±10.0 nm and the zeta potential was 27.03±2.33 mV.