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Recently,hybrid nanoparticles (NPs) consisting of various materials and systems have been investigated to enhance delivery and efficacy of DNA and RNA [1].Among them,lipid-polymer hybrid nanoparticles (LPHNPs) comprising a polymer core and lipid/lipid-PEG shell are one of the versatile carriers due to their complementary characteristics of both polymeric nanoparticles and liposomes [2].