【摘 要】
:
The objective of this study was to compare the in vitro and in vivo performance of rod shaped and spherical like nanocrystals for oral administration.Lovastatin (LOV) was chosen as the model drug and
【机 构】
:
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
【出 处】
:
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
论文部分内容阅读
The objective of this study was to compare the in vitro and in vivo performance of rod shaped and spherical like nanocrystals for oral administration.Lovastatin (LOV) was chosen as the model drug and LOV rod shaped nanocrystals (LOV-RNs) and spherical like nanocrystals (LOV-SNs) were prepared by sonoprecipitation and bead milling, respectively.
其他文献
Human derived cells modeling the gastrointestinal barrier were assessed as an in vitro tool for identifying potential for adverse effects following exposure to protein toxins or innocuous dietary prot
[目的]近年来,转录组学分析技术的迅速发展,为从更加全面的角度理解化合物的生物效应提供了有益的帮助.本研究旨在应用RNA microarray技术结合高通量数据分析,对细颗粒物(PM2.5)引起的肺泡上皮细胞模型(A549)转录组改变及其生物效应进行研究.[材料和方法]100 μ g/mL PM2.5处理A549细胞24h,采用mRNAmicroarray技术分析转录组差异性表达;GO分类发现差异
Historically, studies using laboratory animals such as the in vivo bone marrow MN assay and the in vivo unscheduled DNA synthesis (UDS) assay were used to further evaluate the genotoxic potential of c
[目的]探讨焦炉逸散物接触与焦炉作业工人尿中8-羟基脱氧鸟苷的剂量-效应关系,分析焦炉逸散物对接触工人DNA氧化损伤影响.[材料和方法]采用横断面调查方法,以某焦化厂263名焦炉作业工人为接触组,以某氧气厂113名非焦炉作业工人为对照组,检测两组人群工作场所空气中焦炉逸散物短时间接触浓度.分别采用超高效液相色谱-串联质谱法和高效液相色谱法测定研究对象尿中8-羟基脱氧鸟苷和1-羟基芘水平.1-羟基芘
[目的]该研究采用EpiSkinTM表皮模型(中国生产),以OECD测试指南431"重组人表皮模型体外皮肤腐蚀性测试方法"为执行标准,开展针对体外皮肤腐蚀性测试方法的建立和验证研究,以评估在中国开展基于该表皮模型建立和验证体外皮肤腐蚀性测试方法的可行性.[方法]第一阶段为方法建立阶段,研究人员分别在欧莱雅研发实验室和广东省疾控中心实验室建立OECD测试指南43 1"重组人表皮模型体外皮肤腐蚀性测试
[Aims]Serum creatinine (sCr), blood urea nitrogen (BUN), and serum cystatin C (sCys C) are non-specific traditional biomarkers for monitoring progressive drug-induced kidney injury (DIKI).Most investi
针对皮肤腐蚀性和皮肤刺激性测试,世界经济合作与发展组织(OECD)最新采纳了一个整合测试评估策略,为如何运用模块化手段将已有的和新获得的信息整合在一起对物质进行分类和标识提供了指导(OECD GD203).基于SkinEthicTM重组人类表皮模型(RHE)已于先前被接受纳入皮肤刺激性(OECD TG 439)和皮肤腐蚀性(OECD TG 431)的法规评估方法指南,本项研究的目的旨在评估如何进一
Global hypomethylation, gene-specific methylation and genome instability are common events in tumorigenesis.To date, few studies have examined the aberrant DNA methylation patterns in coke oven worker
The receptor tyrosine kinases, including the EGFR, have been major targets for anticancer therapy since they are abundantly expressed on the cell surface and play an important role in the modulation o
TLR agonists can induce the maturation of dendritc cells and enhance their roles in presenting tumor antigens.ProTα is a small highly acidic polypeptide of 109 amino acid residues in humans, and in me