【摘 要】
：
[Aims]Serum creatinine (sCr), blood urea nitrogen (BUN), and serum cystatin C (sCys C) are non-specific traditional biomarkers for monitoring progressive drug-induced kidney injury (DIKI).Most investi
【机 构】
：
PD&S,Asia Pacific,Janssen Research & Development,Shanghai,China
【出 处】
：
中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛
论文部分内容阅读
[Aims]Serum creatinine (sCr), blood urea nitrogen (BUN), and serum cystatin C (sCys C) are non-specific traditional biomarkers for monitoring progressive drug-induced kidney injury (DIKI).Most investigations of novel DIKI biomarkers have been carried out in rodents.In this study, we evaluated temporal changes in selected novel DIKI biomarkers in male cynomolgus monkeys following intravenous infusion of the nephrotoxicant, Amphotericin B (AmpB).[Materials & Methods] Monkeys (5/group) were intravenously dosed at 0 and 0.4 mg/kg/day for 10 days.All animals were necropsied on Day 11.[Results] AmpB related kidney histopathology findings were characterized primarily as increased intra-tubular crystal deposition [interstitial], increased intra-tubular casts and moderate to mild increased cortical tubular dilatation and basophilia.
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