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  5. Increased Endothelial Progenitor Cell Circulation and VEGF Production in a Rat Model of Noise-Induce

Increased Endothelial Progenitor Cell Circulation and VEGF Production in a Rat Model of Noise-Induce

来源 :The 4th East Asian Symposium on Otology(第四届东亚耳科研讨会) | 被引量 : 0次 | 上传用户：qqzlei
【摘 要】
：
Objective: Noise-induced hearing loss has been associated with alterations in cochlear blood flow.This study analyzed the expression of vascular endothelial Methodology: Acoustic trauma was induced by
【作 者】
：
Dong Yang Zhou Hui Fang 
【机 构】
：
Tian-jin Medical University General Hospital, Tianjin, China
【出 处】
：
The 4th East Asian Symposium on Otology(第四届东亚耳科研讨会)
【发表日期】
：
2014年8期
【关键词】
：
endothelial progenitor cell VEGF hearing loss 
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Objective: Noise-induced hearing loss has been associated with alterations in cochlear blood flow.This study analyzed the expression of vascular endothelial Methodology: Acoustic trauma was induced by white noise at 120 dB SPL for 4 h.Auditory function was evaluated by the auditory brainstem response (ABR) threshold in control (noise-unexposed) rats and in experimental rats at 5 time points after noise exposure.Noise-induced cochlear morphological changes were studied by immunohistochemistry and scanning electron microscopy.VEGF expression was examined by immunohistochemistry and Western blotting analysis.The EPC number was analyzed by flow cytometry of peripheral blood CD34+/CD 133+ cells.
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