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It has been reported that application of norepinephrine(NE)to cerebellar cortex or activation of the locus coeruleus induced a decrease in spontaneous simple spike(SS)firing activity of Purkinje cell(PC).Our previously results indicated that NE bidirectional modulated the spontaneous SS activity of PC via enhancing both inhibitory inputs from molecular layer interneuron(MLI)and excitatory inputs of parallel fibers.