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  5. Protective effect of uric acid on cerebral ischemia and its regulatory action on NO5 and XO

Protective effect of uric acid on cerebral ischemia and its regulatory action on NO5 and XO

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：pigdun
【摘 要】
：
Aim: To investigate the neuro-protective effects and underlying mechanisms of uric acid on rat cerebral ischemia/reperfusion injury in vivo.Methods: Middle cerebral artery occlusion was introduced as
【作 者】
：
Yan YOU Min HU Zhi HE 
【机 构】
：
Medical School of Three Gorges University, Yichang, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
uric acid cerebral ischemia NOS XO 
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Aim: To investigate the neuro-protective effects and underlying mechanisms of uric acid on rat cerebral ischemia/reperfusion injury in vivo.Methods: Middle cerebral artery occlusion was introduced as an in vivo ischernic model in male SD rats.After ischemia impairment, uric acid (6.25 mg/100 g per day, 9.375 mg/100 g per day) was administered by ip for 7 d in treated group.Neurological deficits evaluations were carried out at 6 h after operation.
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