Aim: A human monoclonal antibody was administered intravenously for 4-week in cynomolgus monkeys.The aim of this study was to characterize the toxicity of the antibody and in particular, the exposure-response relationship of the immune-mediated toxicity between these two dose regimens.Methods: Thity-six cynomolgus monkeys (6 monkeys/sex/group, 3 groups) were given intravenous doses of the antibody at either 15 mg/kg QW or 30 mg/kg Q2W for 4 weeks followed by 4 weeks recovery.