Background: Various aberrations such as amplification, deletion and translocation of segmental regions are common features of cancer genomes and play an imp
Background: Silk yield is a typical complex trait of silkworm.To investigate the molecular mechanism underlying the different silk production in silkworm, t
Background: Studies show that cancer may result from somatic alterations in related genes, including point mutation, copy number variations and structural r
Cancer is the term for a collection of various malignant tumor, and has different clinical response based on its tissue.However, they are all caused by the
The first commercial next-generation sequencer (NGS) has born nearly 10 years.The technology had become one of the most exciting and rapid-developing fields
Extremely powerful computers are needed to help biologists to handle big-data traffic jams.Where are extremely powerful computers? Not in USA or Europe, but
The biomedical big data era is coming with the accumulation of high throughput biomedical data, especially the next generation sequencing data.It becomes po
Background: Persistent organic pollutants (POPs) cause various diseases in both human and wildlife and have become a new global environmental problem.The to
Transcripts with stage-specific alternative first exon (SAFE) usage involve in the regulation of many biological processes, yet their presence and functions
The basic unit of chromatin structure is the nucleosome, consisting of histone octamers wrapped in 147 base pairs of DNA.Eukaryotic genomic DNA is assembled