• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Angelica sinensis polysaccharides promote glycosaminoglycan synthesis: Benefiting osteoarthritis

Angelica sinensis polysaccharides promote glycosaminoglycan synthesis: Benefiting osteoarthritis

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：tytytytytytytytytyty
【摘 要】
：
Aim: Loss of glycosaminoglycan (GAG) chains isa typical pathological change of osteoarthritis (OA).Here, effects of Angelica sinensis polysaccharides (ASPs) on GAG synthesis in chondrocytes and the me
【作 者】
：
Yin-xian WEN Jing LI Hui WANG Liao-bin CHEN 
【机 构】
：
Department of Orthopedic Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
ASPs chondrocyte GAG UDP-sugar synthetase glycosyltransferase 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: Loss of glycosaminoglycan (GAG) chains isa typical pathological change of osteoarthritis (OA).Here, effects of Angelica sinensis polysaccharides (ASPs) on GAG synthesis in chondrocytes and the mechanism were studied.Methods: OA Wistar rats orally treated with ASPs (25 mg/kg per day) for 5 weeks were sacrificed for the knee to detect GAG content by Safranin O stain, histopathological changes by Mankins scoring, and protein expression of UDP-sugar synthetases and glycosyl transferases (GTs) involved in GAG synthesis by immunohistochemistry.
其他文献
Hepatoprotective effects of Gentiana manshurica Kitagawa
Aim: Gentiopicroside-containing extract and gentiopicroside from Gentiana manshurica Kitagawa (GM) was investigated for their hepatoprotective effects in vivo.Methods: We applied in vivo model of acet
会议
Gentiana manshurica Kitagawafeminant hepatic failurealcohol steatosis
Anti-proliferative effect of MAM, a natural product on human breast cancer cell MCF7 by inducing apo
Aim: The study was designed to investigate the anti-proliferative effect of MAM, a natural product isolated from Polygonum cuspidatum, on six different human cancer cells and the underlying mechanism
会议
MAMMCF-7 cellcancerapoptosis
Serum amyloid A differentially activates microglia and astrocytes via the PI3K pathway
Aim: Microgtia and astrocytes in the brain play an important role in the development and/or progression of Alzheimers disease (AD).Serum amyloid A (SAA) is a major acute-phase protein produced locally
会议
Alzheimer's diseaseserum amyloid Amicrogliaastrocytes
Adult hippocampal telomerase is implicated in mood disorders
Aim: The aim of the present study is to determine the role of adult hippocampal telomerase in the pathology of mood disorders.Methods: We constructed telomerase reverse transcriptase subunit (TERT) kn
会议
telomerasehippocampusdepressionanxietyaggression
Protective effects of YBBGEP on experimental psoriasis
Aim: YBBGEP is a compound iodine preparation is developed by Yantai Lanxue Pharmaceutical Co Ltd.The purpose of the present study was to investigate the potential protective effects of YBBGEP on the e
会议
YBBGEPpsoriasisprotective effects
Experimental studies of rLj-RGD3, a novel recombinant toxin protein containing three RGD motif from
Aim: The aim of this paper is to investigate the protective effects of recombinant Lampetra Japonica RGD-peptide (rLj-RGD3) on PC12 cells oxygen-glucose deprivation and reperfusion (OGD/RF) injury, an
会议
rLj-RGD3oxygen-glucosedeprivation and reperfusionPC12integrinantiapoptotic
Clonidine improve the performance of learning and memory via increased glutamic acid decarboxylase a
Aim: Clonidine, an α2-adrenergic receptor agonist, has been demonstrated to be neuroprotective when administered during ischemia.It is not known whether clonidine can improve the learning and memory a
会议
clonidineGADischemia injuryspatial learning and memory
HPLC assay validation for KCNQ/M-channel opener QO58-lysin in rat plasma and Its application to phar
The voltage-gated KCNQ/M-potassium channels play a principal role in controlling neuronal excitability.Mutations or inhibition of KCNQ/M-channels can cause neurological diseases, such as myokymia and
会议
KCNQ openerQO58-lysinHPLCpharmacokinetics
Chaperone heat shock protein 70 modulators dual-regulate the development of behavioral sensitization
Aim: Our previous studies have revealed behavioral sensitization, closely relating to drug addiction, mediated by chaperone heat shock protein 70 (Hsp70) in mice.This study aimed to investigate the ef
会议
chaperoneaddictionmorphine
Endoplasmic reticulum stress aggravation as the mechanism underlying Guttiferone K-induced apoptosis
Aim: Guttiferone K (GutK) is a novel cytotoxic compound able to selectively induce apoptosis in colorectal cancer cells.The study proposes endoplasmic reticulum (ER) stress aggravation as the underlyi
会议
Guttiferone Kendoplasmic reticulum aggravationcancer selectivityapoptosis