肺动脉高压(PAH)以肺血管重构为显著特征,其中肺动脉平滑肌细胞异常增殖是构成肺动脉血管重构的主要病理基础.TRPCs是PASMCs细胞膜上的非选择性阳离子通道超家族,对维持细胞内外钙离子浓度具有重要作用,抑制其表达可抑制肺血管重构,缓解肺动脉高压的发生.
Background: Insulin resistance (IR) plays a central role in the development of diabetes and is also a low degree of chronic metabolic inflammation.The obesity and abnormal lipids metabolism increases
Objective: To determine whether the neurotoxin rotenone induces expression and release ofmicroglial proinflammatory cytokine interleukin-6 (IL-6), and whether the selective cysteinyl leukotriene recep
目的:研究黄藤素抗脂多糖致小鼠急性肺损伤的作用.方法:健康雄性成年昆明小鼠随机分为6组:正常对照组;LPS组(气管滴入脂多糖LPS 5 mg/kg);氢化可的松组(腹腔注射氢化可的松3.3mg/kg,每日一次,连续三天,第四天气管滴入LPS 5mg/kg);黄藤素低、中、高剂量组(分别腹腔注射黄藤素2mg/kg、10 mg/kg和50 mg/kg,每日一次,连续三天,第四天气管滴入LPS 5mg/
Objective: This study aimed to investigate the expression of ClC-3, a member of the voltage-gated C1-channel superfarnily, in the endometriotic tissues and the roles of ClC-3 in the migration and inva
Naturally occurring toxins have been invaluable tools for the study of structural andfunctional relationships of voltage-gated sodium channels.Few studies have been made of potential channel-modulatin
Objective:Periarticular and subchondral bone erosion is a significant feature of Rheumatoid Arthritis (RA).It results from osteoclast differentiation and activation triggered by receptor activator of
背景和目的:超极化激活环核苷酸门控阳离子通道(Hyperpolarization-activated Cyclic Nucleotide-gated Channels;HCN)为一类非选择性阳离子通道,目前在哺乳动物中共发现四个亚型,分别为HCN1-HCN4.
目的:超极化激活环核苷酸门控阳离子通道(HCN)参与心脏起搏,疼痛,癫痫等生理病理活动.在人类的窦房结(SAN),HCN4是HCN家族的中最丰富的亚型,而且自2003年起,对HCN4基因几个失去功能的突变体的研究表明,HCN4与窦房结功能障碍关联重大.因此HCN通道阻滞剂是在心脏疾病的治疗的新方法,如伊伐布雷定被批准用于治疗稳定型心绞痛.本论文旨在构建超极化激活环核苷酸门控阳离子通道(HCN)亚型
Objective: Influenza is one of the major global plagues, and to date there are only two types of effective antiviral agents against it in clinic (M2 inhibitors and NA inhibitors).