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The mammalian target ofrapamycin (mTOR) pathway which regulates cell growth, cell survival, metastasis, differentiation and cell motility is often found to be up-regulated in breast cancer.The mTor pathway can be divided into two sub pathways via the mTOR1 and mTOR2 complexes respectively.The mTOR2 complex can be considered to be upstream of the mTOR1 complex through its regulation of AKT which blocks the tuberous sclerosis protein inhibitory complex.