【摘 要】
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It is important to measure embryonic heart myocardial wall strain and strain rate for understanding the mechanisms of embryonic heart development.Optical coherence tomography(OCT)is a powerful tool fo
【机 构】
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College of Information Science and Engineering,Northeastern University,Shenyang China,110004
【出 处】
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2015年中国生物医学工程联合学术年会
论文部分内容阅读
It is important to measure embryonic heart myocardial wall strain and strain rate for understanding the mechanisms of embryonic heart development.Optical coherence tomography(OCT)is a powerful tool for 3D imaging of complex myocardial activities in early stage embryonic hearts with high spatial and temporal resolutions.We develop a novel method to measure strain in embryonic chick heart based on spectral domain OCT images and subsequent image processing.We perform 4D(x,y,z,t)scanning on the outflow tract(OFT)of chick embryonic hearts in HH18 stage(~3 days of incubation).Only one image sequence acquired at the special position is selected based on the Doppler blood flow information where the probe beam penetrates through the OFT perpendicularly.For each image of the selected sequence,the cross-section of the myocardial wall can be approximated as an annulus.The OFT is segmented with a semi-automatic boundary detection algorithm,thus the area and mean circumference of the annular myocardial wall can be achieved.The myocardial wall thickness was calculated using the area divided by the mean circumference,and then the strain was obtained.The results demonstrate that OCT can be a useful tool to describe the biomechanical characteristics of the embryonic heart.
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