【摘 要】
：
The phosphatidylinositol 3-kinase (PI3K)-AKT pathway is involved in various cellular functions,including anti-apoptosis,protein synthesis,glucose metabolism
【机 构】
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Key Laboratory of Marine Biogenetic Resources,Third Institute of Oceanography,State Oceanic Administ
【出 处】
：
福建省海洋学会2014年学术年会暨福建省科协第十四届学术年会分会场
论文部分内容阅读
The phosphatidylinositol 3-kinase (PI3K)-AKT pathway is involved in various cellular functions,including anti-apoptosis,protein synthesis,glucose metabolism and cell cycling.However,the role of the PI3K-AKT pathway in crustaceans remains unclear.In the present study,we cloned and characterized the AKT gene lvakt from Litopenaeus vannamei.The 511-residue LVAKT was highly conserved; contained a PH domain,a catalytic domain and a hydrophobic domain; and was highly expressed in the heart and gills of L.vannamei.We found,using Real-Time Quantitative PCR (Q-PCR) analysis,that lvakt was up-regulated during early white spot syndrome virus (WSSV) infection.Moreover,the PI3K-specific inhibitor,LY294002,reduced viral gene transcription,implying that the PI3K-AKT pathway might be hijacked by WSSV.Our results therefore suggest that LVAKT may play an important role in the shrimp immune response against WSSV.
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