【摘 要】
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Background Cancer stem cells (CSCs),which are considered as the tumor origin and are often resistant to chemotherapy and radiotherapy,are currently a major obstacle for treatment.One particularly intr
【机 构】
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State Key Laboratory of Oncology in Southern China,Cancer Center,Sun Yat-sen University,Guangzhou,51
【出 处】
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2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议
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Background Cancer stem cells (CSCs),which are considered as the tumor origin and are often resistant to chemotherapy and radiotherapy,are currently a major obstacle for treatment.One particularly intriguing property of cancer stem cells is that they express high levels of ABC transporter proteins,especially ABCG2,and then confer their drug-transporting property,thereby resulting in the failure of chemotherapy.Therefore,new therapeutic strategies targeting ABCG2,including downregulation of ABCG2 expression and/or function,may effectively eliminate CSCs and overcome current chemotherapeutic limitations.Here,we investigated the potential effect of afatinib,an irreversible inhibitor of the ErbB family members,on the cancer stem cell-like side population cells.
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