CircRNA CDR1as regulates cell growth via EGFR in hepatocellularcarcinoma cells

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：dsvs123456

【摘要】

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【作者】

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Xue Yang Qian Xiong Feng Ge

【机构】

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Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences,Wuhan 430072

【出处】

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第七届全国生物信息学与系统生物学学术大会

【发表日期】

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2016年8期

【关键词】

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CDR1as EGRF proteomics cell growth

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　　Among the identified thousands of circular RNAs (circRNA) in humans and animals,CDRlas (also known as CiRS-7) was recently demonstrated to act as a powerful miR-7 sponge.Here,we find CDR1as is downregulated in various human cancer cells.To understand the mechanism of action of CDR1as from a system perspective,we employed a quantitative proteomic strategy to systematically identify potential targets of CDR1as in hepatocellularcarcinoma (HHC) cells.The expresssion of 197 proteins was significantly upregulated after overexpress CDR1as,while 135 proteins was downregulated,and we validate the data using western blot.

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CircRNA CDR1as regulates cell growth via EGFR in hepatocellularcarcinoma cells

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