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目的探讨铜绿假单胞菌临床分布及对11种常用抗生素的耐药情况,为临床合理用药提供依据。方法对临床分离到的115株铜绿假单胞菌临床分布及药敏作回顾性分析。结果 115株铜绿假单胞菌,痰及咽拭子中分离出89株(77.4%),尿中分离出11株(9.6%),伤口及分泌物中分离出7株(6.1%);临床科室分布:呼吸内科占22.6%,脑外科占14.8%,ICU中心占12.2%。铜绿假单胞菌对常用抗生素耐药率较低的有亚胺培南(24.3%),美洛培南(25.2%),阿米卡星(26.1%)。结论本院铜绿假单胞菌以呼吸道、泌尿道、伤口感染为主,临床科室以呼吸内科、脑外科及ICU中心为主,其耐药情况相当严重。加强院内感染管理,提倡个体化选择药物及合理使用抗生素对防治铜绿假单胞菌有相当重要意义。
Objective To investigate the clinical distribution of Pseudomonas aeruginosa and its resistance to 11 kinds of commonly used antibiotics to provide basis for clinical rational drug use. Methods The clinical distribution and drug susceptibility of 115 Pseudomonas aeruginosa isolates were retrospectively analyzed. Results Among the 115 strains of Pseudomonas aeruginosa, 89 (77.4%) isolated from sputum and throat swabs, 11 (9.6%) isolated from urine and 7 (6.1%) from wounds and secretions. The clinical Department distribution: Respiratory medicine accounted for 22.6%, 14.8% brain surgery, ICU center accounted for 12.2%. Pseudomonas aeruginosa resistant to commonly used antibiotics, imipenem (24.3%), meropenem (25.2%), amikacin (26.1%). Conclusion Pseudomonas aeruginosa in our hospital is mainly respiratory tract, urinary tract and wound infection. The main clinical departments are respiratory medicine, neurosurgery and ICU center, and their drug resistance is quite serious. To strengthen the management of nosocomial infections, to promote individualized selection of drugs and the rational use of antibiotics is very important for the prevention and treatment of Pseudomonas aeruginosa.