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目的评价去细胞真皮基质对兔巨大肩袖损伤的修复效果。方法将42只成年雄性新西兰大白兔随机分为3组:巨大肩袖损伤常规手术组(对照组,n=18),去细胞真皮基质治疗组(实验组,n=18),正常组(正常组,n=6),对照组和实验组于术后4、8、12周分批随机取出各组12侧肩袖标本行生物力学测试;正常组于12周取出12侧肩袖标本行生物力学测试。结果生物力学测试显示:在术后各个时间点,实验组腱骨界面的断裂载荷显著高于对照组,差异有统计学意义(P<0.01);但术后12周二者腱骨界面的断裂载荷仍显著低于正常组,差异有统计学意义(P<0.05)。结论去细胞真皮基质修补巨大肩袖损伤可增强其腱骨界面的抗拉载荷,有利于巨大肩袖损伤的愈合。
Objective To evaluate the effect of acellular dermal matrix on the repair of giant rotator cuff injury in rabbits. Methods Forty-two adult male New Zealand white rabbits were randomly divided into three groups: normal operation group (control group, n = 18), aortic dermal matrix treatment group (experimental group, n = 18) Group, n = 6). The control group and the experimental group were randomly divided into two groups according to the biomechanical tests of 12 rotator cuffs at 4, 8, and 12 weeks after operation. In the normal group, Mechanical test. Results Biomechanical tests showed that the fracture load of tendon-bone interface in the experimental group was significantly higher than that of the control group at various time points after operation (P <0.01), but fracture load at the tendon-bone interface Still significantly lower than the normal group, the difference was statistically significant (P <0.05). Conclusion Acellular dermal matrix repair of giant rotator cuff injury can increase the tensile load of tendon-bone interface, which is good for the healing of huge rotator cuff injury.