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为了探讨止血作用机制,本文用电子显微镜技术进行了菊三七与参三七对豚鼠血小板超微结构影响的研究。结果表明:10％菊三七注射液与10％参三七注射均能使血小板发生伸展伪足、聚集、变形等粘性变形运动;能使血小板细胞膜破损和部分溶解;能使血小板产生脱颗粒等分泌反应,从而诱致血小板释放ADP、血小板因子Ⅲ和Ca~(2+)等止血活性物质而达到止血作用。对血小板的影响程度与用药剂量成正比。两药作用程度基本相同,作用方式相似。它们对血小板超微结构的影响似与凝血酶类似。本研究结果对菊三七、参三七治疗出血性疾病有临床指导意义。对参三七治疗严重冠心病提出怀疑。
In order to investigate the mechanism of hemostasis, we studied the effects of chrysanthemum indicum and ginseng on ultrastructure of platelets in guinea pigs by electron microscopy. The results showed that: 10% Kusanasi injection and 10% reference Panax notoginseng injection can make the platelet stretch pseudopodia, aggregation, deformation and other viscous deformation movement; platelet membrane can damage and partial dissolution; can platelet degranulation Secretion reaction, which induced release of platelet ADP, platelet factor III and Ca ~ (2 +) and other hemostatic active substances to achieve hemostasis. The degree of influence on platelets is proportional to the dose. The two drugs are basically the same level of action in a similar way. Their effect on platelet ultrastructure resembles that of thrombin. The results of this study of chrysanthemum San, ginseng notoginseng treatment of hemorrhagic disease has clinical significance. On March 27 treatment of serious coronary heart disease raised doubts.