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目的探讨低分子肝素钙治疗重度予痫前期的疗效及治疗期间母儿各项指标的变化。方法选取2009年6月～2011年6月在我院住院的重度子痫前期患者92例,随机分为观察组50例,对照组42例。观察两组血脂代谢水平及相关临床指标的变化。结果观察组较对照组(均经治疗后)血脂水平(血清甘油三脂TG、总胆固醇TC、低密度脂蛋白LDL-c、载脂蛋白B(apoB))有明显下降,尿量增加,尿蛋白总量减少,脐动脉血流S/D比值下降,胎儿窘迫、新生儿窒息率下降,两组产后出血量无明显差异。结论低分子肝素钙治疗重度予痫前期患者,可显著改善治疗效果;低分子肝素钙对母儿安全。
Objective To investigate the effect of low molecular weight heparin on severe preeclampsia and the changes of maternal and infant indexes during the treatment. Methods 92 patients with severe preeclampsia hospitalized in our hospital from June 2009 to June 2011 were randomly divided into observation group (n = 50) and control group (n = 42). The changes of blood lipid metabolism and related clinical indexes were observed. Results The levels of serum lipids (serum TG, TC, LDL-c, apoB) in the observation group were significantly lower than those in the control group (all after treatment) Total protein decreased, umbilical artery blood flow S / D ratio decreased, fetal distress, neonatal asphyxia decreased, there was no significant difference in postpartum hemorrhage between the two groups. Conclusion Low molecular weight heparin treatment of severe pre-eclampsia patients, can significantly improve the treatment effect; low molecular weight heparin calcium for the safety of the mother and child.