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药物首过效应的存在,是降低生物利用度的重要原因之一。产生首过效应的物质基础,是与消化道的血液流向和肝脏对药物具有的代谢转化能力有
The first-pass effect of the drug is one of the important reasons for reducing the bioavailability. The material basis for the first-pass effect is related to the blood flow to the digestive tract and the liver’s ability to metabolize