目的　探讨苯那普利（洛汀新）对慢性肾功能不全（ＣＲＦ）高血压、蛋白尿及肾功能的影响。方法　应用苯那普利治疗了 ３８ 例ＣＲＦ 伴高血压患者。检测了治疗前后血压、尿蛋白定量、血肌肝（Ｓｃｒ）、血尿素氮（ＢＵＮ）及血钾的变化。结果　苯那普利治疗后，血压明显下降（Ｐ＜ ０．０１）；尿蛋白定量明显降低（Ｐ＜ ０．０１）；而Ｓｃｒ、ＢＵＮ 及血钾治疗前后无明显变化（Ｐ＞ ０．０５）。结论　苯那普利能有效地降低ＣＲＦ 患者的高血压、蛋白尿，保护肾功能，延缓ＣＲＦ 进程，是治疗ＣＲＦ 伴高血压的有效药物。 Objective To investigate the effects of benazepril (Lotensin) on hypertension, proteinuria and renal function in patients with chronic renal failure (CRF). Methods Benazepril was used to treat 38 cases of CRF with hypertension. Blood pressure, urinary protein, Scr, BUN and K were measured before and after treatment. Results After benazepril treatment, the blood pressure decreased significantly (P <0.01), while the proteinuria of urine protein decreased significantly (P <0.01), but there was no significant difference between before and after treatment of Scr, BUN and serum potassium ). Conclusion Benazepril can effectively reduce the patients with CRF hypertension, proteinuria, renal function and delay the progression of CRF, is an effective drug for the treatment of CRF with hypertension.