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越来越多的证据表明 ,在动脉瘤性蛛网膜下腔出血 (SAH)后脑血管痉挛 (CVS)的发生发展过程中 ,内皮素 (ET)起着一种关键作用 :ET能够诱发严重而持久的CVS ,SAH后的溶血产物如氧合血红蛋白 ,能增加ET的产生和释放 ,ET可能是一种潜在的循环激素或旁分泌激素 ,许多动物实验显示针对ET的治疗能够缓解CVS。目前针对ET的治疗方法有 :RNA合成抑制剂阻断蛋白质的产生 ,内皮素转换酶抑制剂或反义寡DNA特异性地阻断ET的产生 ,ET -1受体拮抗剂遏制ET -1的生物学作用
There is growing evidence that endothelin (ET) plays a pivotal role in the development of cerebral vasospasm (CVS) following aneurysmal subarachnoid hemorrhage (SAH): ET can induce severe and long-lasting Of CVS, after SAH hemolytic products such as oxyhemoglobin, can increase the production and release of ET, ET may be a potential circulating hormone or paracrine hormone, and many animal experiments show that the treatment of ET can relieve CVS. The current treatment of ET are: RNA synthesis inhibitors block the production of protein, endothelin-converting enzyme inhibitors or antisense oligospecifically block the production of ET, ET-1 receptor antagonist to inhibit ET-1 Biological effects