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根据拼合原理,设计并合成了19个1-(2-羟基-3-芳氧基丙基)-4-芳酰基哌嗪类化合物。对其中8个化合物I_1～I_8进行了药理试验,发现它们有明显的降压活性及α-受体阻滞活性。
According to the principle of assembly, 19 1- (2-hydroxy-3-aryloxypropyl) -4-aroylpiperazines were designed and synthesized. Eight compounds I_1 ~ I_8 were pharmacologically tested and found that they have obvious antihypertensive activity and α-receptor blocking activity.