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目的 :探讨 TECD综合征的临床特征、病程转归以及致病因素。方法 :1对 2 5例临床诊断为 TECD综合征的患者行眼前节检查、角膜厚度检查、角膜内皮细胞形态和数量以及眼压检查。 2认定引起 TECD综合征的化学物质。结果 :1多数 TECD综合征患者同时还伴有大片状或弥漫性虹膜萎缩、瞳孔开大强直和斑块状或颗粒状色素性 KP。 2电镜下发现 TECD综合征患者的角膜内皮细胞和虹膜色素上皮细胞 ,其超微结构出现了明显的异常。 3TECD综合征角膜内皮细胞的丢失率大 ,平均 6 7.6 %。 4TECD综合征会导致角膜内皮细胞不可逆性的功能失代偿 ,形成永久性角膜水肿。大泡性角膜病变和瘢痕性角混膜混浊。 5手术器械残留的消毒剂是导致 TECD综合征的主要原因 ,13眼占 5 2 %。结论 :1除了 Breebaart等归纳的 7个体征外 ,TECD综合征患者还伴有虹膜和瞳孔的异常表现。2 TECD综合征具有发病速度快 ,病变范围广泛 ,预后较差等特征。 3注意将手术器械残留的消毒剂冲洗干净是预防 TECD的关键
Objective: To investigate the clinical features of TECD syndrome, the course of disease and pathogenic factors. Methods: Twenty-five patients with TECD syndrome were examined with anterior segment, corneal thickness, morphology and number of corneal endothelial cells and intraocular pressure. 2 Identify the chemical that causes TECD syndrome. Results: 1 Most of the patients with TECD syndrome also have large or diffuse iris atrophy, dizzy open dilation and plaque or granular pigment KP. 2 electron microscopy found TECD syndrome corneal endothelial cells and iris pigment epithelial cells, the ultrastructure showed significant abnormalities. 3TECD syndrome corneal endothelial cell loss rate, an average of 6 7.6%. 4TECD syndrome can cause corneal endothelial cells irreversible loss of function, the formation of permanent corneal edema. Bullous keratopathy and cicatrisation. 5 Surgical instrument residual disinfectant is the leading cause of TECD syndrome, 13 eyes accounted for 52%. CONCLUSIONS: 1 In addition to the seven signs summarized by Breebaart et al, patients with TECD syndrome are associated with abnormalities in the iris and pupil. 2 TECD syndrome has a fast onset, extensive lesions, poor prognosis and other characteristics. 3 Note that the residual disinfectant surgical instruments to clean TECD is the key to prevention